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The frequency of the e4 allele was significantly higher in the subjects with Alzheimer's disease than in the subjects without dementia(30 percent vs.8 percent,P<0.001).There was a greater accumulation of B-amyloid protein in the brain and more neurofibrillary tangles in the subjects with the e4 allele than in those without it(P<0.001).The deposition of B- amyloid protein varied according to the genotype in both the subjects with dementia and those without dementia:it was lowest in those with the e2/e3 genotype,intermediate in those with the e3/e3 genotype,and highest in those with the e3/e4 genotype.A single subject had the e4/e4 genotype and had dementia.The e4 allele of apolipoprotein E is significantly associated with Alzheimer's disease.Even in elderly subjects without dementia,the apolipoprotein E genotype is related to the degree of deposition of B- amyloid protein in the cerebral cortex. |
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